Folate Efficacy : CerefolinNAC
A medical food for the dietary management of neurovascular oxidative stress and/or hyperhomocysteinemia.
Folate Efficacy
3-year folate therapy gave an individual who is B12 replete the performance of someone:
In a study recently published in The Lancet, Durga, et al. reported that older individuals given folate supplementation for three years had improved memory and ability to process information, as well as a slower rate of age-related cognitive decline.
The study randomly assigned the subjects between the ages of 50 and 70 to receive either a folate supplement or placebo for three years. The study focused on individuals with average plasma total homocysteine concentrations of 13 µmol/L or more and B12 levels of at least 200 pmol/L.
Three years of folate therapy gave an individual the performance of someone nearly 5 years younger for memory, almost 2 years younger for sensorimotor speed (reaction time), 2 years younger for information processing speed (how fast one thinks) and 1½ years younger for global cognitive function (over all mental skills).
Durga J et al. The Lancet 2007; 369:208-216
Normal folate and normal B12 are not enough to decrease the risk of cognitive impairment
According to a recent study appearing in the American Journal of Clinical Nutrition using the most current NHANES (National Health and Nutrition Examination Survey) data on 1302 individuals greater than 60 years of age, normal folate and normal B12 were not enough to decrease the risk of cognitive impairment.
- High folate or normal folate along with low B12 increases the risk of cognitive impairment.
- Cerefolin®NAC provides 2mg methylcobalamin which is as effective if not superior to 1mb B12 given IM.
- Cerefolin®NAC provides the necessary combination of L-methylfolate and B12 (methylcobalamin) to decrease the risks of cognitive impairment.
- The goal for these patients was found to be high folate and normal B12. This is the only combination that actually decreased the risk of cognitive impairment.
- In patients with low B12 with normal or high folate, the risk of cognitive impairment was increased.
Older individuals are more prone to suboptimal levels of B12, and there is growing evidence that folate therapy should be combined with high doses of vitamin B12 to ensure an optimal balance of these 2 vitamins in this group.
Cerefolin®NAC ensures your patient the optimal balance of both folate and B12.