Patient Information : CerefolinNAC

A medical food for the dietary management of neurovascular oxidative stress and/or hyperhomocysteinemia.

Patient Information

The ingredients found in Cerefolin^®NAC are well tolerated in short-term and chronic therapy

• May incur rare and transient headache or GI disturbances.
• Side effects and discontinuation rates similar to placebo in clinical trials ^1-8

Low potential for drug interactions

• High dose folate may result in decreased serum levels of first generation anticonvulsants reducing their effectiveness. No reports have yet linked the same effect with second generation anticonvulsants.
• No interference with anticholinergic medications have been found.

Cerefolin^®NAC requires no titration to target dose or tapering to avoid withdrawal effects.

Cerefolin^®NAC once daily caplet is a starting dose and a maintenance dose.

1. Lehmann M, Regland B, Blennow K, and Gottfries CG. Vitamin B12-B6-Folate treatment improves Blood-Brain Barrier function in patients with Hyperhomocysteinaemia and Mild Cognitive Impairment. Dementia and Geriatric Cognitive Disorders. 2003;16:145-150.
2. Nilsson K, Gustafson L, and Hultberg B. Improvement of cognitive functions after cobalamin/folate supplementation in elderly patients with dementia and elevated plasma homocysteine. International Journal of Geriatric Psychiatry. 2001;16:609-614.
3. Fioravanti M, Ferrario E, Massaia M, Cappa G, Rivolta G, Grossi E and Buckley AE. Low folate levels in the cognitive decline of elderly patients and the efficacy of folate as a treatment for improving memory deficits. Arch Gerontol Geriatr. 1997;26:1-13.
4. Rapin JR, Le Poncin M, Grebyl J. Blood Folates Deficiencies and Cognitive Functions in Aging. In Steinhagen-Thiessen E and Knook DL, ed. Trends in Biomedical Gerontology. Vol. 1. Rijswijk, The Netherlands: TNO Institute for Experimental Gerontology; 1987:221-223.
5. Corrada M, Kawas C, Halldrisch J, Muller D, Brookmeyer R. Reduced risk of Alzheimer's disease with high folate intake: The Baltimore Longitudinal Study of Aging. Alzheimer's & Dementia. 2005;1:11-18.
6. Brocker P, Lebel C, Maurin H, Lods JC. Folate deficiency in elderly subjects: value of folate supplementation in the management of behavior disorders. (In French) Sem Hôp Paris. 1986;62(27):2135-2139.
7. Bryan J, Calvaresi E, and Hughes D. Short-Term Folate, Vitamin B-12 or Vitamin B-6 Supplementation Slightly Affects Memory Performance But Not Mood in Women of Various Ages. J. Nutr. 2002;132:1345-1356.
8. Refsum H, et al. Facts and recommendations about total homocysteine determinations: an expert opinion. Chemical Chemistry. 2004;50(1):3-32.

Cerefolin®NAC is an orally administered prescription medical food for the dietary management of certain metabolic processes identified with early memory loss.
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