Your Memory Matters (www.yourmemorymatters.com) is a website for those with questions about early memory loss.

Oxidative stress is an early event in neuronal death that is linked to memory loss.

Elevated plasma homocysteine has been associated with neuronal cell death. Loss of neurons is associated with loss of acetylcholine, an important neurotransmitter for memory.

Learn how L-methylfolate and methylcobalamin aid in the synthesis of the main memory neurotransmitter, acetylcholine.

L-Methylfolate is the biologically active form of folate, and the only form of folate that is able to cross the blood-brain barrier and is immediately available to the brain.

Methylcobalamin (Methyl-B12) is the principal form of circulating vitamin B12. Recently, studies have shown that cognitive impairment was less marked in those who took folate but also took vitamin B12 supplements.

N-acetylcysteine (NAC) is a precursor to glutathione (GSH), one of the body's most potent natural antioxidants.

Folate supplementation for 3 years significantly improved the cognitive function that declines with age. Among patients with normal B12 status, high serum folate is associated with protection from cognitive impairment.